A recent study (Tzedakis et al., 2018), has shown that the Last Interglacial was punctuated by centennial-scale cold water-mass expansions in the North Atlantic and arid events in S. Europe and suggested that Greenland ice-melt may have contributed to episodic AMOC weakening. By comparison, climate variability during our current interglacial (Holocene, MIS 1) has been relatively subdued. This raises two important questions: are periods warmer than the Holocene climatically more unstable and is this variability related to AMOC changes? To address these questions, we propose to examine a set of ‘natural experiments’: cool interglacials MIS 7a-c and 7e, and warm interglacial MIS 9e and compare them with MIS 5e and 1. Studies have indicated warmer conditions off southern Greenland and extensive GrIS retreat during MIS 5e and 9e, and minimal retreat of the southern GrIS during MIS 1 and 7. The proposed project (VARING) will document the extent of centennial-scale climate variability during these interglacials and explore its origin. We will construct a wide spatio-temporal framework from a network of sites: (1) five North Atlantic records of changes in ocean surface and deep-water conditions; (2) a long pollen sequence from central Italy with an independent chronology, based on dating of volcanic tephras, to provide evidence of the impact of North Atlantic variability on vegetation and precipitation regimes; (3) a ‘rosetta stone’ deep-sea sequence from the Portuguese Margin, linking marine and pollen records in the same core; (4) a North Atlantic – S. Europe stratigraphic lattice with a common chronological framework for the timing and duration of interglacial changes. There are several possible outcomes to our study: (i) no intra-interglacial variability, which places constraints on conditions under which climate remains largely stable; (ii) surface-ocean only variability, leading to less northward oceanic heat transport without a weakening of the deep limb of the AMOC. (iii) surface- and deep-ocean changes, which implies AMOC involvement. By constraining the AMOC components, we will gain greater insight into how ocean circulation changes were occurring and their downstream effects over S. Europe. VARING will go beyond the study of Tzedakis et al. (2018), by deriving records from multiple sites across multiple time intervals with different climate contexts to document changes and explore mechanisms. Ultimately, it will contribute to a step change in our understanding of climate variability across a range of states and will provide much needed constraints on the stability of AMOC under interglacial conditions and its linkage with S. European climate.